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KMID : 0043320170400080915
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Archives of Pharmacal Research
2017 Volume.40 No. 8 p.915 ~ p.920
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New antimicrobial flavonoids and chalcone from Colutea armata
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Inamullah Farah
Fatima Itrat
Khan Sadia
Kazmi Mehdi Hassan
Malik Abdul
Tareen Rasool Bakhsh
Abbas Tanveer
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Abstract
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Colucins A (1) and B (2), new flavonoids and colucone (3), the new chalcone derivative, have been isolated from the CHCl3-soluble fraction of the whole plant of Colutea armata along with luteolin (4), luteolin 7-O-β-D-glucoside (5), isoliquiritigenin (6), trans-caffeic acid (7) and stigmasterol (8) reported for the first time from this species. Their structures were elucidated by spectroscopic techniques including MS and 2D-NMR spectroscopy. Compounds 1 and 2 showed significant antimicrobial activity against two Gram positive and three Gram negative bacterial strains while 3 was moderately active.
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KEYWORD
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Colutea armata, Colucins, Colucone, Antimicrobial activity
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